Impact of brief or extended extinction of a taste aversion on inhibitory associations: Evidence from summation,retardation, and preference tests     

Brooks DC  Bowker JL  Anderson JE  Palmatier MI 《Learning & behavior》2003,31(1):69-84

In five conditioned taste aversion experiments with rats, summation, retardation, and preference tests were used to assess the effects of extinguishing a conditioned saccharin aversion for three or nine trials. In Experiment 1, a summation test showed that saccharin aversion extinguished over nine trials reduced the aversion to a merely conditioned flavor (vinegar), whereas three saccharin extinction trials did not subsequently influence the vinegar aversion. Experiment 2 clarified that result, with unpaired controls equated on flavor exposure prior to testing; the results with those controls suggested that the flavor extinguished for nine trials produced generalization decrement during testing. In Experiment 3, the saccharin aversion reconditioned slowly after nine extinction trials, but not after three. Those results suggested the development of latent inhibition after more than three extinction trials. Preference tests comparing saccharin consumption with a concurrently available fluid (water in Experiment 4, saline in Experiment 5) showed that the preference for saccharin was greater after nine extinction trials than after three. However, saccharin preference after nine extinction trials was not greater, as compared with that for either latent inhibition controls (Experiments 4 and 5) or a control given equated exposures to saccharin and trained to drink saline at a high rate prior to testing (Experiment 5). Concerns about whether conditioned inhibition has been demonstrated in any flavor aversion procedure are discussed. Our findings help explain both successes and failures in demonstrating postextinction conditioned response recovery effects reported in the conditioned taste aversion literature, and they can be explained using a memory interference account.  相似文献   

师生冲突的概念界定与分类探究——基于刘易斯·科塞的冲突分类理论   总被引：15，自引：0，他引：15  

田国秀 《教师教育研究》2003,15(6):40-45

论文通过借鉴和辨析社会学理论中的冲突概念,对师生冲突概念作出界定。根据美国当代社会学家刘易斯·科塞的冲突分类理论,对学校师生冲突进行分类研究。在此基础上提出了三个观点:学校师生冲突的多数属于非现实性冲突;师生结构由紧密走向松散是师生冲突增多的重要原因;师生冲突具有一定的正面功能。  相似文献   

Land degradation,government subsidy,and smallholders’ conservation decision: the case of the loess plateau in China     

石敏俊 《浙江大学学报(A卷英文版)》2004,5(12):1533-1542

Land degradation is one of the severe environmental problems in China. In order to combat land degradation, a soil conservation program was introduced since 2000 to reduce soil erosion by converting slope-cultivated land into forestry and pasture. This paper represents the first systematic attempt to investigate the impact of the soil conservation program on land degradation in the loess plateau. The results indicate that the soil conservation program to convert slope fields into forest or pasture is an effective way to combat soil erosion. However, a subsidy that is higher than profit of land use activity of slope fields before their conversion into forest and pasture is needed to encourage farmers to join the conservation program. A policy measure to encourage and assist farmers to develop sedentary livestock by using crops produced from fields as well as fodder and forage grass from the converted slope fields might contribute to combat soil erosion. Increase in off-farm job opportunities may encourage households to reduce cultivation in slope fields. That implies a policy measure to encourage rural urbanization might contribute to combat soil erosion.  相似文献   

China’s graduate students need better education in scientific writing and publishing     

Chun-jie?Zhang  Yuan?ZhuEmail author 《Journal of Zhejiang University. Science. B》2016,17(5):409-412

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Yangxueqingnao particles inhibit rat vascular smooth muscle cell proliferation induced by lysophosphatidic acid   总被引：1，自引：0，他引：1  

Cai W  Xu Y  Chen JZ  Huang SR  Lu ZY  Wang ZK 《Journal of Zhejiang University. Science. B》2005,6(9):892-896

Objective: To observe the effect of Yangxueqingnao particles on rat vascular smooth muscle cell (VSMC) proliferation induced by lysophosphatidic acid (LPA). Methods: The amount of3H-TdR (3H-thymidine) admixed in cultured rat VSMC was measured and mitogen-activated protein kinase (MAPK) activity and lipid peroxidation end product malondialdehyde (MDA)content of the VSMC were assayed. Results: 1×10-9, 1×10-8, 1×10-7 mol/L LPA in a concentration dependent manner, induced the amount of 3H-TdR admixed, MAP kinase activity, and MDA content of the cultured rat VSMC to increase. However, 5%, 10%,and 15% Yangxueqingnao serum preincubation resulted in a decrease of 23.0%, 42.0%, and 52.0% (P＜0.01) respectively in the amount of 3H-TdR admixed, a decline in VSMC MAP kinase activity of 13.9% (P＜0.05), 29.6% (P＜0.01), and 48.9% (P＜0.01)respectively, and also, a decrease in MDA content of VSMC of 19.4%, 24.7%, and 43.2% (P＜0.01) respectively, in the 1×10-7mol/L LPA-treated VSMC. Conclusions: LPA activates the proliferation and lipid peroxidation of VSMC in a concentration dependent manner. The LPA-induced VSMC proliferation is related to the activity of MAP kinases, enzymes involved in an intracellular signalling pathway. The results of the present study showed that Yangxueqingnao particles can effectively inhibit LPA-induced VSMC proliferation, MAP kinase activation, and reduce lipid peroxidative lesion.  相似文献   

The inadequacy of individual educational program (IEP) goals for high school students with word-level reading difficulties     

Catone WV  Brady SA 《Annals of dyslexia》2005,55(1):53-78

This investigation analyzed goals from the Individual Educational Programs (IEPs) of 54 high school students with diagnosed reading disabilities in basic skills (decoding and/or word identification). Results showed that for 73% of the students, the IEPs written when they were in high school failed to specify any objectives regarding their acute difficulties with basic skills. IEPs from earlier points in the students’ educations were also reviewed, as available. For 23 of the students, IEPs were present in the students’ files for three time points: elementary school (ES), middle school (MS), and high school (HS). Another 20 students from the sample of 54 had IEPs available for two time points (HS and either MS or ES). Comparisons with the IEPs from younger years showed a pattern of decline from ES to MS to HS in the percentage of IEPs that commented on or set goals pertaining to weaknesses in decoding. These findings suggest that basic skills deficits that persist into the upper grade levels are not being sufficiently targeted for remediation, and help explain why older students frequently fail to resolve their reading problems.  相似文献   

Investigation on apoptosis of neuronal cells induced by Amyloid beta-Protein     

罗本燕  徐增斌  陈智  陈峰  唐敏 《浙江大学学报(A卷英文版)》2004,5(8):989-994

Objective: To construct a PC12 cell strain with neuronal differentiation, and observe the apoptosis and pro-liferation activity effects induced these cells by Amyloid beta-Protein (Aβ-43). Methods: 1) PC12 cells in logarithmicgrowth phase were subcultured for 24 h. After the culture fluid was changed, the cells were treated with Rat-β-NGF andcultured for 9 days. 2) Neuronal differentiation of PC12 cells in logarithmic growth phase were divided into four groups:control group (0), experimental group (1), experimental group (2) and experimental group (3). The concentrations of Aβ inthe four groups were 0 μmol/L, 1.25 μ mol/L, 2.5 μ mol/L and 5 μmol/L, respectively. The cells were harvested at 24, 48 and72 h later and stained with AnnexinV-FITC/PI after centrifugation and washing. Then flow cytometry was conducted toexamine the apoptosis percentage. 3) NGF-induced PC12 cells were selected and Aβ with different concentrations wasadded. The final concentrations of Aβ were 0 μmol/L, 1.25 μmol/L, 2.5 μmol/L and 5 μ mol/L, respectively. After the cellswere incubated in an atmosphere of 5% CO2 at 37 ℃ in an incubator for 72 h, the OD values were examined. Results: 1)Neuronal differentiated PC 12 cell lines were successfully established. 2) Flow cytometric examination indicated that Aβ(1.25, 2.5, and 5.0 μmol/L) could effectively induce apoptosis of neuronal-differented cells at the 24 h, 48 h and 72 h timepoints. 3) Aβ (0-5.00 μ mol/L) had no obvious effect on proliferation or restraining of the neuronal differentiation of thePC 12 cells after a 72 h interacting process. Conclusion: This investigation revealed successful neuronal differentiation of thePC12 cell strain. The induction of apoptosis of the neurocytes by various concentrations of Aβ was observed and the in-fluence of Aβ on induced proliferation of PC 12 cells by Rat-β-NGF was revealed. This study -05 provide basis for futureresearch on the molecular cure of AD and interdiction of AD evolution.  相似文献   

African Oral Traditions: Riddles Among The Haya of Northwestern Tanzania     

Johnson?M.?IshengomaEmail author 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2005,51(2-3):139-153

This study argues for the integration of African oral traditions and other elements of traditional learning into the modern school curriculum. It thus contributes to supporting the increased relevance of education to local communities. In particular, using the example of riddles collected from one of the main ethnic groups in Northwestern Tanzania, the Haya people, the present study challenges the views of those social and cultural anthropologists who hold that African riddles have no substantially meaningful educational value. Instead, it is maintained that riddles make an important contribution to children’s full participation in the social, cultural, political, and economic life of African communities, especially by fostering critical thinking and transmitting indigenous knowledge.

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Zusammenfassung MÜNDLICHE TRADITIONEN IN AFRIKA: DER ERZIEHERISCHE WERT VON RÄTSELN BEI DEN HAYA IM NORDWESTLICHEN TANSANIA – Diese Studie argumentiert für die Einbeziehung afrikanischer mündlicher Traditionen und anderer Elemente traditionellen Lernens in den modernen schulischen Lehrplan. Sie fördert somit die gestiegene Bedeutung der Bildung für die örtlichen Gemeinschaften. Insbesondere begegnet die vorliegende Studie, indem sie das Beispiel von Rätseln gebraucht, die bei einer der Hauptvolksgruppen im nordwestlichen Tansania, dem Volk der Haya, gesammelt wurden, den Ansichten derjenigen Sozial- und Kulturanthropologen, die behaupten, dass afrikanische Rätsel keinen wesentlich bedeutungsvollen erzieherischen Wert haben. Stattdessen wird die These aufgestellt, dass Rätsel einen wichtigen Beitrag zur vollständigen Teilnahme von Kindern am gesellschaftlichen, kulturellen, politischen sowie wirtschaftlichen Leben afrikanischer Gemeinschaften leisten, besonders durch die Förderung von kritischem Denken und die Weitergabe des Wissens der Eingeborenen.

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Resumen TRADICIONES ORALES AFRICANAS: EL VALOR EDUCATIVO DE LAS ADIVINANZAS PARA EL PUEBLO DE LOS HAYA EN EL NOROESTE DE TANZANÍA – Con este trabajo, el autor aboga por una integración de tradiciones orales africanas y de otros elementos de aprendizaje tradicional en los actuales planes de estudios de las escuelas. Al mismo tiempo, hace énfasis en la creciente relevancia que la educación tiene para las comunidades locales. Con este estudio, el autor desafía la posición de aquellos antropólogos sociales y culturales que sostienen que las adivinanzas africanas no tienen ningún valor educativo digno de mención, ante todo presentando el ejemplo de adivinanzas que ha recopilado entre los miembros del pueblo de los haya, uno de los principales grupos étnicos del noroeste de Tanzanía. Por lo contrario, el autor afirma que las adivinanzas promueven en gran medida la participación plena de los niños en la vida social, cultural, política y económica de las comunidades africanas, ante todo porque incentivan el pensamiento crítico y transmiten conocimientos indígenas.

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Résumé TRADITIONS ORALES AFRICAINES : LA VALEUR ÉDUCATIVE DES ÉNIGMES CHEZ LES HAYAS DE LA TANZANIE DU NORD-OUEST – Cette étude argumente en faveur de l’intégration des traditions orales africaines et autres éléments de l’apprentissage traditionnel dans le programme d’étude de l’école moderne. Elle contribue ainsi à soutenir la pertinance accrue de l’éducation au sein des communautés locales. En particulier, utilisant l’exemple des énigmes recueillies chez l’un des principaux groupes ethniques de la Tanzanie du Nord-Ouest, le peuple Haya, l’étude présente conteste les vues de ces anthropologues sociaux et culturels qui soutiennent que les énigmes africaines n’ont pas de valeur éducative substantiellement significative. Au lieu de cela, on maintient que les énigmes apportent une contribution importante à la pleine participation des enfants à la vie sociale, culturelle, politique et économique des communautés africaines, spécialement en ce qu’elles favorisent la pensée critique et transmettent les connaissances indigènes.

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Enhancing cellular immune response to HBV M DNA vaccine in mice by codelivery of interleukin-18 recombinant     

陈建忠  朱海红  刘克洲  陈智 《浙江大学学报(A卷英文版)》2004,5(4):467-471

Objective: To investigate the effect of interleukin-18 (IL-18) on immune response induced by plasmid encoding hepatitis B virus middle protein antigen and to explore new strategies for prophylactic and therapeutic HBV DNA vaccines. Methods: BALB/c mice were immunized with pCMV-M alone or co-immunized with pcDNA3-18 and pCMV-M and then their sera were collected for analysing anti-HBsAg antibody by ELISA; splenocytes were isolated for detecting specific CTL response and cytokine assay in vitro. Results: The anti-HBs antibody level of mice co-immunized with pcDNA3-18 and pCMV-M was slightly higher than that of mice immunized with pCMV-M alone, but there was not significantly different (P>0.05). Compared with mice injected with pCMV-M, the specific CTL cytotoxity activity of mice immunized with pcDNA3-18 and pCMV-M was significantly enhanced (P<0.05) and the level of IFN-γ in supernatant of splenocytes cultured with HBsAg in vitro was significantly elevated (P<0.05) while the level of IL-4 had no significant difference (P>0.05). Conclusion: The plasmid encoding IL-18 together with HBV M gene DNA vaccines may enhance specific TH1 cells and CTL cellular immune response induced in mice, so that IL-18 is a promising immune adjuvant.  相似文献   

The contribution of epistemology to curriculum construction in the sciences     

Denis?C.?PhillipsEmail author 《Zeitschrift für Erziehungswissenschaft》2003,6(3):421-431

Summary The paper focuses upon curriculum planning in the scientific disciplines at university level, although it is claimed the argument may be of wider applicability. Drawing upon the writings of philosophers of education from several decades ago (notably Schwab and Scheffler) whose work is too often overlooked in contemporary debates about the curriculum, and using illustrative examples from the author’s own experience, it is argued that too often the focus of science curriculum planning is the “rhetoric of conclusions” or the “substantive structure” — the current state of knowledge at the forefront of the respective disciplines — to the neglect of what Schwab called the “syntactical structure” of the sciences (which roughly approximates their epistemology). This aspect of these disciplines is essential for the general student trying to become familiar with the nature of science as a broad field of knowledge, for prospective teachers, and — contra Scheffler’s view — for students who aim at careers as researchers.

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Zusammenfassung Der Beitrag der Epistemologie zur Curriuculumkonstruktion in den Naturwissenschaften Der Aufsatz fokussiert auf die Curriculumplanung für den naturwissenschaftlichen Unterricht in der universit?ren Lehrerausbildung, wenngleich behauptet wird, dass dieses Argument weitreichendere Anwendbarkeit besitzt. Der Text knüpft an erziehungswissenschaftlichen Schriften (insbesondere von Schwab und Scheffler) an, deren Ver?ffentlichung zwar einige Dekaden zurückliegt, deren Beitrag in den aktuellen Debatten aber oft übersehen wird. Darüber hinaus werden einige illustrative Beispiele aus dem Erfahrungsschatz des Autors genutzt, um zu zeigen, dass der Fokus der Curriculumplanung für die Naturwissenschaften — dem augenblicklichen Wissensstand der zu berücksichtigenden Disziplinen zufolge — zu oft in einer „Rhetorik der Schlussfolgerung“ oder „substantivischen Struktur“ besteht, was dazu führt, dass das, was Schwab die „syntaktische Struktur“ der Naturwissenschaften nennt (und ihrer Epistemologie ziemlich nahe kommt), vernachl?ssigt wird. Dieser Aspekt jener Disziplinen ist besonders wichtig für Studierende, die allgemeinbildend vertraut werden m?chten mit den Naturwissenschaften, für angehende Lehrer und — entgegen Schefflers Ansicht — für Studenten, die eine Karriere als Forscher anstreben.

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“When walking in quicksand country, carry a stout pole — it will help you get out should you need to. As soon as you start to sink, lay the pole on the surface of the quicksand. Flop onto your back on top of the pole. Work the pole to a new position: under your hips and at right angles to your spine. Take the shortest route to firmer ground, moving slowly.” Piven/Borgenicht 1999, p. 18

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This paper was presented at the conference Silence Between the Disciplines, Berlin-Brandenburg Academy of Sciences, Berlin, October 2002.  相似文献